In vitro knowledge have been discovered that characterize cytochrome P-450 (CYP-450) enzymes as prospective important contributors to the main metabolism of various exogenous cannabinoids, and scientific pharmacogenetic information further assist CYP2C9 as an important contributor to THC metabolism, as well as a pharmacokinetic interaction review u

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It really is concluded that EAM-2201 has the potential to bring about in vivo pharmacokinetic drug interactions when co-administered with substrates of CYP2C8, CYP3A4 and UGT1A3, and it is evaluated in pooled human liver microsomes. EAM-2201 was incubated with human hepatocytes for three h inside of a CO2 incubator and also the metabolites of E